Thoracic and Sleep Group Queensland People caring for how you breathe and sleep

June 15, 2017

Could a blood test predict OSA?

Filed under: Blog — Tags: , , , , , , — Trent Segal @ 4:23 am

OSA is linked to common cardiovascular risk factors such as obesity, high blood pressure and type 2 diabetes.  Having a blood test is common place as part of a general checkup at the doctors to give important information about possible diabetes, high cholesterol or that there is some other dysfunction in the body.

Common blood tests include the Monocyte count which are a type of white blood cell.  High numbers of these indicate the body is fighting off an infection or may also indicate a more serious blood disorder.  High density lipoproteins (HDL) are also commonly measured along with low density lipoproteins (LDL) and triglycerides which together are used as an indicator of heart health which may show possible early signs of atherosclerosis and cardiovascular disease.

A recent study has looked at the Monocyte to HDL ratio (MHR) in the blood serum and if the ratio was a predictor for obstructive sleep apnoea.

The investigators found that OSA patients (AHI>5 and excessive daytime tiredness) had a significantly lower monocyte to HDL ratio (MHR) to that of controls (AHI <5).  Furthermore, they also found significant differences in the MHR between subgroups of mild, moderate and severe OSA.

These findings suggest the MHR, easily performed by a blood test, could be a useful predictor for OSAS.  Another reason to go to have a regular checkup at the doctor.

https://www.ncbi.nlm.nih.gov/pubmed/28607881

 

May 29, 2017

March 23, 2017

Obesity, Sleep Apnoea, and Heart Surgery

Filed under: Blog — Tags: , , , , , , , , — Mark Russell-Pavier @ 1:25 am

A study recently published in Chest investigated obesity, sleep disordered breathing and complications after cardiac surgery. Atrial fibrillation, the complication being investigated, is an abnormal heart rhythm characterised by rapid and irregular beating; a disruption in the electrical system of your heart.

The study took large group of 190 people. Each person had done a sleep study, and then had cardiac surgery within three years. The investigation aimed to use that data to determine whether sleep apnoea is a risk factor for post-cardiac surgery atrial fibrillation. Whilst the study concluded that there was no association between the two, the methodology may be flawed.

The study took the AHI of the patients, and adjusted it for obesity, and then compared that to atrial fibrillation numbers. By doing this they may have eliminated a great deal of the variation in AHI, thereby making it difficult to form a statistical association. Perhaps a better way of investigating the relationship would be to split the group of patients into three; one with sleep apnoea and no obesity, one with obesity, and one with sleep apnoea and obesity. The difference between the three groups might have investigated the relationship more conclusively.

Kaw, Roop et al. “Obesity As An Effect Modifier In Sleep Disordered Breathing And Post-Cardiac Surgery Atrial Fibrillation”. Chest (2017): n. pag. Web. 23 Mar. 2017.

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