New research suggests a hormone released from fat tissue is critical in the development of obesity-related asthma and may be a target of future treatments for the disease. Along with genetic susceptibility and environmental exposures, obesity is emerging as a risk factor for asthma. Many studies have shown obesity also affects the course of asthma. However, scientists do not understand how obesity contributes to asthma. An estimated 40 percent of people with asthma have obesity.
The study looked at the adipose hormone aP2, which is increased in the circulation of humans and animals with obesity. It is involved in the body’s inflammatory responses and previously has been shown to contribute to chronic inflammatory diseases associated with obesity, such as diabetes and heart disease.
In the new study, they measured aP2 levels in blood and lung fluid of people with and without asthma. They found aP2 levels were 25.4 percent higher in the blood of people who were affected by asthma and met the criteria for obesity or being overweight, compared with people without asthma. Higher levels of aP2 were associated with asthma status only in people with overweight or obesity. There was no significant difference in aP2 levels in normal-weight people with and without asthma.
They also measured aP2 levels in lung fluid collected from 13 people with obesity and 36 normal-weight people with and without asthma. They found aP2 levels from the individuals with obesity were 23 percent higher compared with the other study participants.
The researchers say that these data suggest that aP2 may be an independent risk factor for obesity-related asthma. Furthermore, the findings also suggest anti-aP2 treatments can impede obesity-related asthma development and its chronic complications.
Source:
The Endocrine Society. “Adipose hormone may play role in obesity-related asthma.” ScienceDaily. ScienceDaily, 25 March 2019.
